Structural and biophysical characterization of murine rif1 C terminus reveals high specificity for DNA cruciform structures.


Mammalian Rif1 is a key regulator of DNA replication timing, double-stranded DNA break repair, and replication fork restart. Dissecting the molecular functions of Rif1 is essential to understand how it regulates such diverse processes. However, Rif1 is a large protein that lacks well defined functional domains and is predicted to be largely intrinsically… (More)
DOI: 10.1074/jbc.M114.557843


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