Structural and biological constraints on diversity of regions immediately upstream of cleavage sites in calicivirus precursor proteins.

@article{Oka2009StructuralAB,
  title={Structural and biological constraints on diversity of regions immediately upstream of cleavage sites in calicivirus precursor proteins.},
  author={Tomoichiro Oka and Masaru Yokoyama and Kazuhiko Katayama and Hiroshi Tsunemitsu and Mami Yamamoto and Kana Miyashita and Satoko Ogawa and Kazushi Motomura and Hirohiko Mori and Hiromi Nakamura and Takaji Wakita and Naokazu Takeda and Hironori Sato},
  journal={Virology},
  year={2009},
  volume={394 1},
  pages={
          119-29
        }
}
To address the regulation and evolution of precursor protein cleavability in caliciviruses, we examined constraints on diversity of upstream regions of calicivirus precursor cleavage sites. We performed alanine scanning and supplementary mutagenesis of amino acids at P1, P2, P3, and P4 sites using four viruses representing the four major genera of the family Caliciviridae. This study complements previous mutagenesis studies and shows strong restrictions in mutations at the P1 and P4 sites for… CONTINUE READING
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