Structural and biochemical comparison of the anti-mitotic agents colchicine, combretastatin A4 and amphethinile.

@article{McGown1989StructuralAB,
  title={Structural and biochemical comparison of the anti-mitotic agents colchicine, combretastatin A4 and amphethinile.},
  author={A. T. McGown and Brian W. Fox},
  journal={Anti-cancer drug design},
  year={1989},
  volume={3 4},
  pages={249-54}
}
The novel agents amphethinile and combretastatin A4 are shown to be very similar to colchicine in their interactions with purified tubulin. All three agents can inhibit tubulin assembly at similar treatment levels and have comparable affinity constants for tubulin. Amphethinile and combretastatin A4 are capable of displacing colchicine but not vinblastine from tubulin. A comparison of the structures of these agents shows that whereas colchicine and combretastatin A4 contain a trimethoxybenzene… CONTINUE READING

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