Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA.

Abstract

The extreme toxicity of botulinum neurotoxins (BoNTs) relies on their specific cleavage of SNARE proteins, which eventually leads to muscle paralysis. One newly identified mosaic toxin, BoNT/HA (aka H or FA), cleaves VAMP-2 at a unique position between residues L54 and E55, but the molecular basis underlying VAMP-2-recognition of BoNT/HA remains poorly… (More)
DOI: 10.1093/femspd/fty044

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