Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function

@inproceedings{Rorke2015StructuralAB,
  title={Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function},
  author={Ellen A. Rorke and Gautam Adhikary and Christina A. Young and Robert H. Rice and Peter M Elias and Debbie Crumrine and John R. Meyer and M Blumenberg and Richard L Eckert},
  booktitle={Cell Death and Disease},
  year={2015}
}
Epidermal keratinocyte differentiation on the body surface is a carefully choreographed process that leads to assembly of a barrier that is essential for life. Perturbation of keratinocyte differentiation leads to disease. Activator protein 1 (AP1) transcription factors are key controllers of this process. We have shown that inhibiting AP1 transcription factor activity in the suprabasal murine epidermis, by expression of dominant-negative c-jun (TAM67), produces a phenotype type that resembles… CONTINUE READING

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