Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors

@article{Wehrman2007StructuralAM,
  title={Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors},
  author={Tom S Wehrman and Xiaolin He and Bill Raab and Abhiram Dukipatti and Helen M. Blau and K. Christopher Garcia},
  journal={Neuron},
  year={2007},
  volume={53},
  pages={25-38}
}

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The results indicate that the trkA and p75 receptors can potentially interact, and that such an association may be responsible for the generation of high affinity NGF binding sites.

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Two unique functions are suggested for the high affinity heteromeric NGF receptor site: integration of both the MAPK and Akt pathways in the production of NGF-induced neurite outgrowth, and rapid and sustained activation of the Akt pathway, with consequent long term cellular survival.

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