Structural and Functional Plasticity at the Axon Initial Segment

  title={Structural and Functional Plasticity at the Axon Initial Segment},
  author={Rei Yamada and Hiroshi Kuba},
  booktitle={Front. Cell. Neurosci.},
The axon initial segment (AIS) is positioned between the axonal and somato-dendritic compartments and plays a pivotal role in triggering action potentials (APs) and determining neuronal output. It is now widely accepted that structural properties of the AIS, such as length and/or location relative to the soma, change in an activity-dependent manner. This structural plasticity of the AIS is known to be crucial for homeostatic control of neuronal excitability. However, it is obvious that the… CONTINUE READING

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