Structural and Functional Organization of the Gene Encoding the Human Thyrotropin‐Releasing Hormone Receptor

@article{Matre1999StructuralAF,
  title={Structural and Functional Organization of the Gene Encoding the Human Thyrotropin‐Releasing Hormone Receptor},
  author={Vilborg Matre and Per Ivar H{\o}vring and Sigurd {\O}rstavik and Eirik Frengen and Edith Rian and Zlatibor M Velickovic and Rosalind P. Murray‐Mcintosh and Kaare M. Gautvik},
  journal={Journal of Neurochemistry},
  year={1999},
  volume={72}
}
Abstract : The thyrotropin‐releasing hormone (TRH) receptor (TRHR) is widely distributed throughout the central and peripheral nervous systems. In addition to its role in controlling the synthesis and secretion of thyroid‐stimulating hormone and prolactin from the anterior pituitary, TRH is believed to act as a neurotransmitter as well as a neuromodulator. We have isolated genomic λ and P1‐derived artificial chromosome clones encoding the human TRHR. The gene was found to be 35 kb with three… Expand
Mapping, CDNA Cloning and Tissue Expression of the Porcine Thyrotropin-Releasing Hormone Receptor Gene
TLDR
Real-time quantitative RT-PCR showed that the mRNA of pTRHR is expressed in a variety of tissues, with high expression in the brain, hypothalamus, pituitary, testis, and fat tissue, and potential direct action of TRH on lipocyte might exist. Expand
The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb.
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It is reported here that the human TRHR promoter contains 11 putative response elements for the haematopoietic transcription factor c-Myb and is highly Myb-responsive in transfection assays, implying a novel functional link between the neuroendocrine and the immune systems at the level of promoter regulation. Expand
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TLDR
It is concluded that the TRH-signaling elements examined are, in general, not directly involved in the mechanisms causing paradoxical GH secretion in acromegalic patients. Expand
The TRHR Gene Is Associated with Hypothalamo-Pituitary Sensitivity to Levothyroxine
TLDR
An association between serum TSH levels and discrete alleles of the TR HR gene in totally thyroidectomized patients under LT4 therapy is demonstrated and the TRHR gene seems to be a determinant of hypothalamo-pituitary sensitivity to LT4. Expand
Disorders of thyrotropin synthesis, secretion, and function.
  • S. Rose
  • Medicine
  • Current opinion in pediatrics
  • 2000
Advances related to thyrotropin during 1999 included better understanding of the genetic basis of pituitary development and genetic advances in identifying clinical entities and their mechanisms andExpand
The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways
TLDR
Two relevant molecular mechanisms linked to central hypothyroidism and macroorchidism in I GSF1 deficiency are identified, revealing IGSF1 as an important regulator of TGFβ/Activin pathways in the pituitary. Expand
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A cDNA encoding the human thyrotropin-releasing hormone receptor (hTRH-R) was isolated from a human brain cDNA library. Screening of 1.2 million clones resulted in 2 candidates. The largest cloneExpand
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Knowing the genomic organization and the promoter region of thyrotropin-releasing hormone (TRH) receptor gene will allow further studies of possible disorders of the TRH receptor, as well as facilitate elucidation of transcriptional control of the human TRH receptors gene. Expand
Two isoforms of the thyrotropin-releasing hormone receptor generated by alternative splicing have indistinguishable functional properties.
TLDR
Functional expression in Xenopus laevis oocytes indicates that both cDNAs encode fully functional TRH receptors, and the perfect colinearity between genomic DNA and TRH-R(412) cDNA demonstrates that no other introns are present within the coding region of the TRH receptor gene. Expand
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TLDR
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The cloning and characterization of the mouse TRH receptor (TRH-R) gene revealed an untranslated exon (exon 1), a single intron and an upstream dinucleotide repeat sequence (d(TG)16.d(AG)21) in theExpand
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TLDR
RT-PCR analysis indicated TRHR mRNA to be expressed in the pituitary and brain and the deduced amino acid sequence of bovine TRHR exceeded 88% that of mouse, rat or human. Expand
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