Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase

@inproceedings{Feng2014StructuralAF,
  title={Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase},
  author={Boya Feng and Chandra Sekhar Mandava and Qiang Guo and Jie Wang and Wei Cao and Ningning Li and Yixiao Zhang and Yanqing Zhang and Zhixin Wang and Jiawei Wu and Suparna Sanyal and Jianlin Lei and Ning Gao},
  booktitle={PLoS biology},
  year={2014}
}
Obg proteins are a family of P-loop GTPases, conserved from bacteria to human. The Obg protein in Escherichia coli (ObgE) has been implicated in many diverse cellular functions, with proposed molecular roles in two global processes, ribosome assembly and stringent response. Here, using pre-steady state fast kinetics we demonstrate that ObgE is an anti-association factor, which prevents ribosomal subunit association and downstream steps in translation by binding to the 50S subunit. ObgE is a… CONTINUE READING

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