Structural and Functional Evolution of Vertebrate Neuroendocrine Stress Systems

  title={Structural and Functional Evolution of Vertebrate Neuroendocrine Stress Systems},
  author={Robert J. Denver},
  journal={Annals of the New York Academy of Sciences},
  • R. Denver
  • Published 1 April 2009
  • Biology
  • Annals of the New York Academy of Sciences
The vertebrate hypothalamus–pituitary–adrenal (HPA; or interrenal) axis plays pivotal roles in animal development and in physiological and behavioral adaptation to environmental change. The HPA, or stress axis, is organized in a hierarchical manner, with feedback operating at several points along the axis. Recent findings suggest that the proteins, gene structures, and signaling pathways of the HPA axis were present in the earliest vertebrates and have been maintained by natural selection owing… 

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Epigenetics/Programming in the HPA Axis.

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Regulation of vertebrate corticotropin-releasing factor genes.

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Evolution of the Corticotropin‐releasing Hormone Signaling System and Its Role in Stress‐induced Phenotypic Plasticity

  • R. Denver
  • Biology
    Annals of the New York Academy of Sciences
  • 1999
Corticotropin‐releasing hormone may be a phylogenetically ancient developmental signaling molecule that allows developing organisms to escape deleterious changes in their larval/fetal habitat.

CRF and stress in fish.

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Negative regulation of corticotropin releasing factor expression and limitation of stress response

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