Structural and Functional Determinants of γ-Secretase, an Intramembrane Protease Implicated in Alzheimer’s Disease

@article{Fraering2007StructuralAF,
  title={Structural and Functional Determinants of γ-Secretase, an Intramembrane Protease Implicated in Alzheimer’s Disease},
  author={Patrick C. Fraering},
  journal={Current Genomics},
  year={2007},
  volume={8},
  pages={531 - 549}
}
Alzheimer's disease is the most common form of neurodegenerative diseases in humans, characterized by the progressive accumulation and aggregation of amyloid-beta peptides (Abeta) in brain regions subserving memory and cognition. These 39-43 amino acids long peptides are generated by the sequential proteolytic cleavages of the amyloid-beta precursor protein (APP) by beta- and gamma-secretases, with the latter being the founding member of a new class of intramembrane-cleaving proteases (I-CliPs… CONTINUE READING