Structural and Functional Characterization of a Complex between the Acidic Transactivation Domain of EBNA2 and the Tfb1/p62 Subunit of TFIIH

@inproceedings{Chabot2014StructuralAF,
  title={Structural and Functional Characterization of a Complex between the Acidic Transactivation Domain of EBNA2 and the Tfb1/p62 Subunit of TFIIH},
  author={Philippe Chabot and Luca Raiola and Mathieu Lussier-Price and Thomas O Morse and Genevi{\`e}ve Arseneault and Jacques Archambault and James G Omichinski},
  booktitle={PLoS pathogens},
  year={2014}
}
Infection with the Epstein-Barr virus (EBV) can lead to a number of human diseases including Hodgkin's and Burkitt's lymphomas. The development of these EBV-linked diseases is associated with the presence of nine viral latent proteins, including the nuclear antigen 2 (EBNA2). The EBNA2 protein plays a crucial role in EBV infection through its ability to activate transcription of both host and viral genes. As part of this function, EBNA2 associates with several host transcriptional regulatory… CONTINUE READING
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Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53

  • P Di Lello, LM Jenkins, TN Jones, BD Nguyen, T Hara
  • Mol Cell
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