Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs

@inproceedings{Kumar2016StructuralAF,
  title={Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs},
  author={Ramakrishnan B. Kumar and Lin Zhu and Helena Idborg and Olof R{\aa}dmark and P. -J. Jakobsson and Agnes Rinaldo-Matthis and Hans Hebert and Caroline Jegersch{\"o}ld},
  booktitle={PloS one},
  year={2016}
}
An important step in the production of inflammatory mediators of the leukotriene family is the Ca2+ mediated recruitment of 5 Lipoxygenase (5LO) to nuclear membranes. To study this reaction in vitro, the natural membrane mimicking environment of nanodiscs was used. Nanodiscs with 10.5 nm inner diameter were made with the lipid POPC and membrane scaffolding… CONTINUE READING