Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding

Abstract

ALIX/AIP1 functions in enveloped virus budding, endosomal protein sorting, and many other cellular processes. Retroviruses, including HIV-1, SIV, and EIAV, bind and recruit ALIX through YPX(n)L late-domain motifs (X = any residue; n = 1-3). Crystal structures reveal that human ALIX is composed of an N-terminal Bro1 domain and a central domain that is… (More)
DOI: 10.1016/j.cell.2007.01.035

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