Structural and Biochemical Analysis of a Single Amino-Acid Mutant of WzzBSF That Alters Lipopolysaccharide O-Antigen Chain Length in Shigella flexneri

@inproceedings{Chang2015StructuralAB,
  title={Structural and Biochemical Analysis of a Single Amino-Acid Mutant of WzzBSF That Alters Lipopolysaccharide O-Antigen Chain Length in Shigella flexneri},
  author={Chiung-Wen Chang and Elizabeth Ngoc Hoa Tran and Daniel Jesper Ericsson and Lachlan W. Casey and Thierry G. A. Lonhienne and Friederike M C Benning and Renato Morona and Bostjan Kobe and Renwick C J Dobson},
  booktitle={PloS one},
  year={2015}
}
Lipopolysaccharide (LPS), a surface polymer of Gram-negative bacteria, helps bacteria survive in different environments and acts as a virulence determinant of host infection. The O-antigen (Oag) component of LPS exhibits a modal chain-length distribution that is controlled by polysaccharide co-polymerases (PCPs). The molecular basis of the regulation of Oag chain-lengths remains unclear, despite extensive mutagenesis and structural studies of PCPs from Escherichia coli and Shigella. Here, we… CONTINUE READING
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