Structural and Antimicrobial Features of Peptides Related to Myticin C, a Special Defense Molecule from the Mediterranean Mussel Mytilus galloprovincialis.

@article{Domeneghetti2015StructuralAA,
  title={Structural and Antimicrobial Features of Peptides Related to Myticin C, a Special Defense Molecule from the Mediterranean Mussel Mytilus galloprovincialis.},
  author={Stefania Domeneghetti and Marco Franzoi and Nunzio Damiano and Rosa Pia Norante and Nancy M El Halfawy and Stefano Mammi and Oriano Marin and Massimo Bellanda and Paola Venier},
  journal={Journal of agricultural and food chemistry},
  year={2015},
  volume={63 42},
  pages={9251-9}
}
Mussels (Mytilus spp.) have a large repertoire of cysteine-stabilized α,β peptides, and myticin C (MytC) was identified in some hundreds of transcript variants after in vivo immunostimulation. Using a sequence expressed in Italian mussels, we computed the MytC structure and synthesized the mature MytC and related peptide fragments (some of them also prepared in oxidized form) to accurately assess their antibacterial and antifungal activity. Only when tested at pH 5 was the reduced MytC as well… CONTINUE READING