Structural analysis of variant and invariant genes in trypanosomes.

  title={Structural analysis of variant and invariant genes in trypanosomes.},
  author={Nina Agabian and Linda S Thomashow and Michael Milhausen and Kenneth Stuart},
  journal={The American journal of tropical medicine and hygiene},
  volume={29 5 Suppl},
Variant surface antigens have been purified from variants of a newly developed serodeme of Trypanosoma brucei 164, and found to be distinct by immunological and molecular criteria. cDNA clones containing variant and invariant gene sequences were isolated by using RNA from different variants and cloned DNAs from other systems as probes. These trypanosome and heterologous cloned DNAs were used as probes of trypanosome gene structure and activity. Regulation of variant antigen gene expression is… CONTINUE READING