Structural analysis of the yeast SWI/SNF chromatin remodeling complex

@article{Smith2003StructuralAO,
  title={Structural analysis of the yeast SWI/SNF chromatin remodeling complex},
  author={Corey L. Smith and Rachel A. Horowitz-Scherer and Joan Frances Flanagan and Christopher L. F. Woodcock and Craig L. Peterson},
  journal={Nature Structural Biology},
  year={2003},
  volume={10},
  pages={141-145}
}
Elucidating the mechanism of ATP-dependent chromatin remodeling is one of the largest challenges in the field of gene regulation. One of the missing pieces in understanding this process is detailed structural information on the enzymes that catalyze the remodeling reactions. Here we use a combination of subunit radio-iodination and scanning transmission electron microscopy to determine the subunit stoichiometry and native molecular weight of the yeast SWI/SNF complex. We also report a three… 
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Multiple functions of the SWI/SNF complex in eukaryotes are discussed in regulating gene transcription, mRNA splicing, and DNA damage response and the potentials in exploiting chromatin remodeling for management of crop disease are presented.
SWI/SNF Chromatin-remodeling Factors: Multiscale Analyses and Diverse Functions*
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The role of SWI/SNF in human diseases, including cancer and viral infections is addressed; recent genomic and proteomic advances are highlighted; and the biochemistry of these complex enzymes is reviewed.
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It is demonstrated that the docking domain of histone H2A is essential for SWI/SNF and RSC induced nucleosome sliding and the reason for inability of these nucleosomes to slide is due to a faulty generation of ‘Remosome' intermediates.
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TLDR
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