Structural analysis of the yeast SWI/SNF chromatin remodeling complex

@article{Smith2003StructuralAO,
  title={Structural analysis of the yeast SWI/SNF chromatin remodeling complex},
  author={Corey L. Smith and Rachel A. Horowitz-Scherer and Joan Frances Flanagan and Christopher L. F. Woodcock and Craig L. Peterson},
  journal={Nature Structural Biology},
  year={2003},
  volume={10},
  pages={141-145}
}
Elucidating the mechanism of ATP-dependent chromatin remodeling is one of the largest challenges in the field of gene regulation. One of the missing pieces in understanding this process is detailed structural information on the enzymes that catalyze the remodeling reactions. Here we use a combination of subunit radio-iodination and scanning transmission electron microscopy to determine the subunit stoichiometry and native molecular weight of the yeast SWI/SNF complex. We also report a three… 
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TLDR
Electron microscopy of the RSC chromatin-remodeling complex reveals a ring of protein densities around a central cavity that could explain the ability of RSC to expose nucleosomal DNA in the presence of ATP without loss of associated histones.
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TLDR
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TLDR
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TLDR
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