Structural analysis of the role of TPX2 in branching microtubule nucleation

@inproceedings{AlfaroAco2017StructuralAO,
  title={Structural analysis of the role of TPX2 in branching microtubule nucleation},
  author={Raymundo Alfaro-Aco and Akanksha Thawani and Sabine Petry},
  booktitle={The Journal of cell biology},
  year={2017}
}
The mitotic spindle consists of microtubules (MTs), which are nucleated by the γ-tubulin ring complex (γ-TuRC). How the γ-TuRC gets activated at the right time and location remains elusive. Recently, it was uncovered that MTs nucleate from preexisting MTs within the mitotic spindle, which requires the protein TPX2, but the mechanism basis for TPX2 action is… CONTINUE READING