Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins.

@article{Roux1998StructuralAO,
  title={Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins.},
  author={Kenneth H. Roux and Andrew S Greenberg and L H Greene and Lioudmila Strelets and David W. Avila and Elizabeth C. McKinney and Martin F. Flajnik},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 20},
  pages={11804-9}
}
We recently have identified an antigen receptor in sharks called NAR (new or nurse shark antigen receptor) that is secreted by splenocytes but does not associate with Ig light (L) chains. The NAR variable (V) region undergoes high levels of somatic mutation and is equally divergent from both Ig and T cell receptors (TCR). Here we show by electron microscopy that NAR V regions, unlike those of conventional Ig and TCR, do not form dimers but rather are independent, flexible domains. This unusual… CONTINUE READING

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Roux et al

  • Y. Harpaz, Chothia, C. J. Mol. Biol. 238, 528–539. Immunology, Evolution
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

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