Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.

Abstract

Aberrant signaling of ErbB family members human epidermal growth factor 2 (HER2) and epidermal growth factor receptor (EGFR) is implicated in many human cancers, and HER2 expression is predictive of human disease recurrence and prognosis. Small molecule kinase inhibitors of EGFR and of both HER2 and EGFR have received approval for the treatment of cancer… (More)
DOI: 10.1074/jbc.M110.206193

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Cite this paper

@article{Aertgeerts2011StructuralAO, title={Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.}, author={Kathleen Aertgeerts and Robert J Skene and Jason K Yano and B. C. Sang and Hua Zou and Gyorgy Snell and Andy Jennings and Keiji Iwamoto and Noriyuki Habuka and Aki Hirokawa and Tomoyasu Ishikawa and Toshimasa Tanaka and Hiroshi Miki and Yoshikazu Ohta and Satoshi Sogabe}, journal={The Journal of biological chemistry}, year={2011}, volume={286 21}, pages={18756-65} }