Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors.

@article{Zhu1999StructuralAO,
  title={Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors.},
  author={Xiaotian Zhu and Joseph L Kim and John R. Newcomb and Paul E Rose and David R. Stover and L M Toledo and Huilin Zhao and Kurt A Morgenstern},
  journal={Structure},
  year={1999},
  volume={7 6},
  pages={651-61}
}
BACKGROUND The lymphocyte-specific kinase Lck is a member of the Src family of non-receptor tyrosine kinases. Lck catalyzes the initial phosphorylation of T-cell receptor components that is necessary for signal transduction and T-cell activation. On the basis of both biochemical and genetic studies, Lck is considered an attractive cell-specific target for the design of novel T-cell immunosuppressants. To date, the lack of detailed structural information on the mode of inhibitor binding to Lck… CONTINUE READING

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