Structural analysis of the choline-binding protein ChoX in a semi-closed and ligand-free conformation.


The periplasmic ligand-binding protein ChoX is part of the ABC transport system ChoVWX that imports choline as a nutrient into the soil bacterium Sinorhizobium meliloti. We have recently reported the crystal structures of ChoX in complex with its ligands choline and acetylcholine and the structure of a fully closed but substrate-free state of ChoX. This… (More)
DOI: 10.1515/BC.2009.113


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