Structural analysis of the catalytic domain of tetanus neurotoxin.

@article{Rao2005StructuralAO,
  title={Structural analysis of the catalytic domain of tetanus neurotoxin.},
  author={K. N. N. Rao and Desigan Kumaran and Thomas Binz and Subramanyam Swaminathan},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2005},
  volume={45 7},
  pages={929-39}
}
Clostridium neurotoxins, comprising the tetanus neurotoxin and the seven antigenically distinct botulinum neurotoxins (BoNT/A-G), are among the known most potent bacterial protein toxins to humans. Although they have similar function, sequences and three-dimensional structures, the substrate specificity and the selectivity of peptide bond cleavage are different and unique. Tetanus and botulinum type B neurotoxins enzymatically cleave the same substrate, vesicle-associated membrane protein, at… CONTINUE READING

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