Structural analysis of ricin and implications for inhibitor design.

  title={Structural analysis of ricin and implications for inhibitor design.},
  author={Jon D. Robertus and Xiaoping Yan and Steffen Ernst and Arthur F. Monzingo and Seth Joseph Worley and Peter Day and Thomas Hollis and M Svinth},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={34 11-12},
Ricin is a potent cytotoxin with experimental and clinical uses; it has also been used as a poison. There is considerable interest in identifying or designing inhibitors of the toxin that could be administered as antidotes. The X-ray structure of ricin A-chain is known and a plausible mechanism of action has been proposed. This provides a structural and chemical framework around which inhibitors could be designed; such a structure-based project is underway. Computer programs such as DOCK, GRID… CONTINUE READING