Structural analysis of receptor tyrosine kinases.

  title={Structural analysis of receptor tyrosine kinases.},
  author={Stevan R Hubbard},
  journal={Progress in biophysics and molecular biology},
  volume={71 3-4},
Receptor tyrosine kinases (RTKs) are single-pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma-phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism. Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor… CONTINUE READING


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