Structural analysis of inhibitor binding to human carbonic anhydrase II.

@article{BoriackSjodin1998StructuralAO,
  title={Structural analysis of inhibitor binding to human carbonic anhydrase II.},
  author={P. Ann Boriack-Sjodin and Scott Zeitlin and Helen H Chen and L Crenshaw and Shmuel Gross and Anura P Dantanarayana and Paula Delgado and Jeremy A May and Thomas J. Dean and David W Christianson},
  journal={Protein science : a publication of the Protein Society},
  year={1998},
  volume={7 12},
  pages={2483-9}
}
X-ray crystal structures of carbonic anhydrase II (CAII) complexed with sulfonamide inhibitors illuminate the structural determinants of high affinity binding in the nanomolar regime. The primary binding interaction is the coordination of a primary sulfonamide group to the active site zinc ion. Secondary interactions fine-tune tight binding in regions of… CONTINUE READING