Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity.

Abstract

Antibodies may be viewed as adaptor molecules that provide a link between humoral and cellular defence mechanisms. Thus, when antigen-specific IgG antibodies form antigen/antibody immune complexes the effectively aggregated IgG can activate a wide range of effector systems. Multiple effector mechanisms result from cellular activation mediated through a… (More)

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