Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors.

Abstract

The inhibitory activities against DNA polymerases (pols) of catechin derivatives (i.e., flavan-3-ols) such as (+)-catechin, (-)-epicatechin, (-)-gallocatechin, (-)-epigallocatechin, (+)-catechin gallate, (-)-epicatechin gallate, (-)-gallocatechin gallate, and (-)-epigallocatechin gallate (EGCg) were investigated. Among the eight catechins, some catechins… (More)

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@article{Mizushina2005StructuralAO, title={Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors.}, author={Yoshiyuki Mizushina and Akiko Saito and Akira Tanaka and Noriyuki Nakajima and Isoko Kuriyama and Masaharu Takemura and Toshifumi Takeuchi and Fumio Sugawara and Hiromi Yoshida}, journal={Biochemical and biophysical research communications}, year={2005}, volume={333 1}, pages={101-9} }