Structural analysis of a human glial variant laminin.

  title={Structural analysis of a human glial variant laminin.},
  author={Ellen K Lemosy and Virginia A. Lightner and Harold P Erickson},
  journal={Experimental cell research},
  volume={227 1},
Astrocytes secrete laminin-like molecules in culture and may represent a major source of laminin in the developing central nervous system, yet these laminins have not been extensively characterized. We previously reported the presence of an astrocyte-derived variant laminin in media conditioned by human U251 MG astrocytoma cells. This laminin was partially purified in a highly anionic Mono Q fraction with strong adhesion activity for fibroblasts and glial cells (Aukhil et al. (1990) Matrix 10… CONTINUE READING