Structural analysis of a fungal methionine synthase with substrates and inhibitors.

Abstract

The cobalamin-independent methionine synthase from Candida albicans, known as Met6p, is a 90-kDa enzyme that consists of two (βα)8 barrels. The active site is located between the two domains and has binding sites for a zinc ion and substrates L-homocysteine and 5-methyl-tetrahydrofolate-glutamate3. Met6p catalyzes transfer of the methyl group of 5-methyl… (More)
DOI: 10.1016/j.jmb.2014.02.006

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