Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex

@article{Bowman2004StructuralAO,
  title={Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex},
  author={G. Bowman and M. O’Donnell and J. Kuriyan},
  journal={Nature},
  year={2004},
  volume={429},
  pages={724-730}
}
Sliding clamps are ring-shaped proteins that encircle DNA and confer high processivity on DNA polymerases. Here we report the crystal structure of the five-protein clamp loader complex (replication factor-C, RFC) of the yeast Saccharomyces cerevisiae, bound to the sliding clamp (proliferating cell nuclear antigen, PCNA). Tight interfacial coordination of the ATP analogue ATP-γS by RFC results in a spiral arrangement of the ATPase domains of the clamp loader above the PCNA ring. Placement of a… Expand
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