Structural analysis of DegS, a stress sensor of the bacterial periplasm.

  title={Structural analysis of DegS, a stress sensor of the bacterial periplasm.},
  author={Kornelius Zeth},
  journal={FEBS letters},
  volume={569 1-3},
Regulated proteolysis is a key event in transmembrane signalling between intracellular compartments. In Escherichia coli the membrane-bound protease DegS has been identified as the periplasmic stress sensor for unfolded outer membrane proteins (OMPs). DegS inititates a proteolytic cascade resulting in the release of sigmaE the transcription factor of periplasmic genes. The crystal structure of DegS protease reported at 2.2 A resolution reveals a trimeric complex with the monomeric protease… CONTINUE READING
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