Structural analysis of ATP analogues compatible with kinase-catalyzed labeling.

@article{Suwal2012StructuralAO,
  title={Structural analysis of ATP analogues compatible with kinase-catalyzed labeling.},
  author={Sujit Suwal and Chamara Senevirathne and Satish Garre and Mary Kay H Pflum},
  journal={Bioconjugate chemistry},
  year={2012},
  volume={23 12},
  pages={2386-91}
}
Kinase-catalyzed protein phosphorylation is an important biochemical process involved in cellular functions. We recently discovered that kinases promiscuously accept γ-modified ATP analogues as cosubstrates and used several ATP analogues as tools for studying protein phosphorylation. Herein, we explore the structural requirements of γ-modified ATP analogues for kinase compatibility. To understand the influence of linker length and composition, a series of ATP analogues was synthesized, and the… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
1 Extracted Citations
0 Extracted References
Similar Papers

Similar Papers

Loading similar papers…