Structural analyses of fibrinogen amyloid fibrils.

  title={Structural analyses of fibrinogen amyloid fibrils.},
  author={Louise C. Serpell and Merrill D L Benson and Juris J. Liepnieks and Paul E. Fraser},
  journal={Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis},
  volume={14 3},
Hereditary fibrinogen amyloidosis is characterized by deposition of amyloid fibrils in renal glomeruli. The subunit protein of the amyloid fibrils is a proteolytic fragment of the fibrinogen Aalpha-chain. To investigate the structure of fibrinogen amyloid, fibrils were extracted from the tissues of a patient and studied by X-ray fiber diffraction and electron microscopy. We have carried out a full structural characterization of amyloid fibrils taken from disease tissue. These studies revealed… CONTINUE READING

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