Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization

@inproceedings{Sun2013StructuralAA,
  title={Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization},
  author={Siyang Sun and Ye Xiang and Wataru Akahata and Heather A. Holdaway and Pankaj Pal and Xinzheng Zhang and Michael S Diamond and Gary J. Nabel and Michael G. Rossmann},
  booktitle={eLife},
  year={2013}
}
A 5.3 Å resolution, cryo-electron microscopy (cryoEM) map of Chikungunya virus-like particles (VLPs) has been interpreted using the previously published crystal structure of the Chikungunya E1-E2 glycoprotein heterodimer. The heterodimer structure was divided into domains to obtain a good fit to the cryoEM density. Differences in the T = 4 quasi-equivalent heterodimer components show their adaptation to different environments. The spikes on the icosahedral 3-fold axes and those in general… CONTINUE READING
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A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection

  • W Akahata, ZY Yang, H Andersen, S Sun, HA Holdaway, WP Kong
  • Nat Med 16:334–8
  • 2010
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