Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABA(A) receptors.

Abstract

Biphenylic compounds related to the natural products magnolol and 4'-O-methylhonokiol were synthesized, evaluated and optimized as positive allosteric modulators (PAMs) of GABA(A) receptors. The most efficacious compounds were the magnolol analog 5-ethyl-5'-hexylbiphenyl-2,2'-diol (45) and the honokiol analogs 4'-methoxy-5-propylbiphenyl-2-ol (61), 5-butyl… (More)
DOI: 10.1016/j.bmc.2014.10.027

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Cite this paper

@article{Fuchs2014StructuralAO, title={Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABA(A) receptors.}, author={Alexander Fuchs and R. Baur and Clara T. Schoeder and Erwin Sigel and Christa E. M{\"u}ller}, journal={Bioorganic & medicinal chemistry}, year={2014}, volume={22 24}, pages={6908-17} }