Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.

@article{Ulrich2010StructuralAO,
  title={Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.},
  author={Natalie Christine Ulrich and John Kodet and Nolan R. Mente and Craig Heath Kuder and John A. Beutler and Raymond J. Hohl and David F. Wiemer},
  journal={Bioorganic \& medicinal chemistry},
  year={2010},
  volume={18 4},
  pages={
          1676-83
        }
}

Figures and Tables from this paper

Relevance of the C-5 position to schweinfurthin induced cytotoxicity.

Stilbenes as κ-Selective, Non-nitrogenous Opioid Receptor Antagonists

TLDR
Assays on two compounds determined that one shows potent opioid receptor binding activity and significantly improved selectivity for the κ receptor, and these studies begin to illuminate the structural features of these non-nitrogenous opioid receptor antagonists that are required for activity.

Semi-synthesis, structural modification and biological evaluation of 5-arylbenzofuran neolignans

TLDR
Most derivatives revealed low cytotoxic effects suggesting that they were relatively safer than the natural 5-arylbenzofuran neolignan, and the selectivity assay for cytotoxicity showed tumor cells were more sensitive to the promising compounds than normal cells.

Schweinfurthins: Lipid Modulators with Promising Anticancer Activity.

TLDR
A in-depth look at the history of schweinfurthins, their synthesis, where the research presently stands, and the questions that remain is taken.

Alkenylphosphonates: unexpected products from reactions of methyl 2-[(diethoxyphosphoryl)methyl]benzoate under Horner-Wadsworth-Emmons conditions.

Methyl 2-[(diethoxyphosphoryl)methyl]benzoate reacts with several aldehydes to produce an alkenylphosphonate as the major product, together with varying amounts of the expected

Modern natural products drug discovery and its relevance to biodiversity conservation.

  • D. Kingston
  • Environmental Science, Biology
    Journal of natural products
  • 2011
TLDR
Results from International Cooperative Biodiversity Groups working in Madagascar, Panama, and Suriname are used as examples of what can be achieved when biodiversity conservation is linked to drug discovery.

References

SHOWING 1-10 OF 25 REFERENCES

Synthesis of nonracemic 3-deoxyschweinfurthin B.

TLDR
This represents the first synthesis of the tetracyclic schweinfurthin skeleton, validating the overall synthetic strategy and providing the first schwe infurthin analogue with activity slightly greater than those of the natural products.

Cytotoxic geranyl stilbenes from Macaranga schweinfurthii.

TLDR
The cytot toxicity profile of the schweinfurthins tested in the NCI 60-cell screen was similar to that of the stelletins and cephalostatins, suggesting that these structurally diverse natural products may share similar mechanisms of cytotoxicity.

Total synthesis of (+)-schweinfurthins B and E.

TLDR
The first total synthesis of (+)-schweinfurthin B, a potent and differentially active cytotoxic agent, has been accomplished and established for the first time the absolute stereochemistry of the natural product, and provides access to material on a scale that will advance biological studies.

BF3 x Et2O-mediated cascade cyclizations: synthesis of schweinfurthins F and G.

TLDR
The total synthesis of the natural stilbene (+)-schweinfurthin G has been accomplished through a sequence based on an efficient cationic cascade cyclization through a novel reaction with a phenolic oxygen "protected" as its MOM ether.

Schweinfurthin D, A Cytotoxic Stilbene from Macaranga schweinfurthii

Abstract A novel cytotoxic stilbene, schweinfurthin D, was isolated from Macaranga schweinfurthii (Euphorbiaceae) and its structure was determined by spectroscopic methods. Schweinfurthin D showed

Cytotoxic triterpenes from a marine sponge, Stelletta sp.

Bioassay-guided fractionation of an extract of a marine sponge, Stelletta sp., has led to the isolation and characterization of four new cytotoxic isomalabaricane triterpenes, named stellettins C

Synthesis and biological evaluation of dihydrobenzofuran lignans and related compounds as potential antitumor agents that inhibit tubulin polymerization.

TLDR
2-phenyl-dihydrobenzofuran derivatives constitute a new group of antimitotic and potential antitumor agents that inhibit tubulin polymerization.