Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.

@article{Ulrich2010StructuralAO,
  title={Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.},
  author={Natalie C Ulrich and John G. Kodet and Nolan R. Mente and C. Kuder and J. Beutler and R. Hohl and D. Wiemer},
  journal={Bioorganic & medicinal chemistry},
  year={2010},
  volume={18 4},
  pages={
          1676-83
        }
}
  • Natalie C Ulrich, John G. Kodet, +4 authors D. Wiemer
  • Published 2010
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or molecular target has inspired our efforts to prepare both the natural products and analogues. In this paper, chemical synthesis of analogues modified in different olefinic positions, and preliminary results from studies of their biological activity, are reported. 
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