Structural alterations in the DNA ahead of the primer terminus during displacement synthesis by reverse transcriptases.

@article{Winshell2001StructuralAI,
  title={Structural alterations in the DNA ahead of the primer terminus during displacement synthesis by reverse transcriptases.},
  author={Jamie Winshell and James J. Champoux},
  journal={Journal of molecular biology},
  year={2001},
  volume={306 5},
  pages={
          931-43
        }
}
Unlike most DNA polymerases, reverse transcriptases can initiate DNA synthesis at a single-strand break and displace the downstream non- template strand simultaneously with extension of the primer. This reaction is important for generation of the long terminal repeat sequences in the duplex DNA product of retroviral reverse transcription. Oligonucleotide-based model displacement constructs were used to study the interaction of human immunodeficiency virus type 1 and Moloney murine leukemia… CONTINUE READING
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