Structural alterations and conformational dynamics in Holliday junctions induced by binding of a site-specific recombinase.

@article{Lee1998StructuralAA,
  title={Structural alterations and conformational dynamics in Holliday junctions induced by binding of a site-specific recombinase.},
  author={J. Lee and Y. A. Voziyanov and Shailja Pathania and Makkuni Jayaram},
  journal={Molecular cell},
  year={1998},
  volume={1 4},
  pages={
          483-93
        }
}
Binding of a cleavage-incompetent mutant of the Flp recombinase induces a roughly square-planar geometry in synthetic immobile Holliday junctions. The branch points, which are rigidly fixed in these junctions in their free forms, tend to be more flexible in their protein-bound forms. Our results (1) suggest a plausible mechanism for the switching of the recombination complex from the Holliday-forming mode to the Holliday-resolving mode, (2) provide a rationale for previous observations that Flp… CONTINUE READING

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  • 2012
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