Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus

  title={Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus},
  author={L. Coussens and Charles Van Beveren and D. Smith and E. Chen and R. Mitchell and C. Isacke and I. Verma and A. Ullrich},
  • L. Coussens, Charles Van Beveren, +5 authors A. Ullrich
  • Published 1986
  • Biology, Medicine
  • Nature
  • A role for proto-oncogenes in the regulation and modulation of cell proliferation1,2 has been suggested by the findings that the B-chain of platelet-derived growth factor (PDGF) is encoded by the proto-oncogene sis3–7 and that the erb-B oncogene product is a truncated form of the epidermal growth factor (EGF) receptor8–10. Furthermore, the product of the proto-oncogene fms (c-fms) may be related or identical to the receptor for macrophage colony-stimulating factor (CSF-1)11. v-fms is the… CONTINUE READING
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