Structural adaptability of zinc binding sites: different structures in partially, fully, and heavy-metal loaded states.

@article{Heinz2009StructuralAO,
  title={Structural adaptability of zinc binding sites: different structures in partially, fully, and heavy-metal loaded states.},
  author={Uwe Gunreben Heinz and Lars Hemmingsen and Martin Kiefer and Hans-Werner Adolph},
  journal={Chemistry},
  year={2009},
  volume={15 30},
  pages={7350-8}
}
The present study demonstrates that both the nature (Zn(II), Cd(II) or Hg(II)) and supply of metal ions determine whether zinc fingers fold into the well-known, fully loaded structures or alternatively populate a variety of structural states under substoichiometric conditions. Metal-bridged species are observed by perturbed angular correlation (PAC), EXAFS, UV spectroscopy, and stopped-flow kinetics. Transitions between structural states as adaptive reactions to changed metal-ion supply might… CONTINUE READING