Structural abnormalities of endoscopy-negative reflux disease--real or perceived?

  title={Structural abnormalities of endoscopy-negative reflux disease--real or perceived?},
  author={Michael Vieth},
  volume={78 Suppl 1},
About two thirds of individuals affected by gastroesophageal reflux disease suffer from endoscopy-negative esophageal reflux disease. Often, these individuals do not receive adequate medication. In contrast, erosive reflux disease is much better defined and even subclassified as mucosal breaks of the esophageal epithelium. It is known from large trials that gastroesophageal reflux disease is probably not a categorical disease without further progression. On the other hand, the first structural… CONTINUE READING


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