Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study

@article{Ludvigson2010StructuralAI,
  title={Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study},
  author={Adam E. Ludvigson and Jennifer I. Luebke and Jada Lewis and Alan Peters},
  journal={Brain Structure and Function},
  year={2010},
  volume={216},
  pages={31-42}
}
rTg4510 transgenic (TG) mice overexpress mutant (P301L) human tau protein. We have compared the dorsal premotor cortex of TG mice versus non-transgenic (NT) mice at 4, 9, and 13 months of age, using light (LM) and electron microscopy (EM). LM assessment shows that cortical thickness in TG mice is reduced by almost 50% from 4 to 13 months of age, while at… CONTINUE READING

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