Structural abnormalities in deficit and nondeficit schizophrenia.

  title={Structural abnormalities in deficit and nondeficit schizophrenia.},
  author={Robert W. Buchanan and Alan Breier and Brian Kirkpatrick and Ahmed Elkashef and Robert C. Munson and F. E. Gellad and William T. Carpenter},
  journal={The American journal of psychiatry},
  volume={150 1},
OBJECTIVE Previous studies have suggested the involvement of the frontal and parietal cortices and thalamus in a neural circuit underlying the production of primary enduring negative or deficit symptoms of schizophrenia. The purpose of this study was to examine whether structural changes in the proposed circuit are associated with the production of deficit symptoms. METHOD Magnetic resonance imaging was used to measure the volume of selected circuit brain regions (i.e., the prefrontal region… CONTINUE READING