Structural Transitions Mediating Transcription Initiation by T7 RNA Polymerase

@article{Mukherjee2002StructuralTM,
  title={Structural Transitions Mediating Transcription Initiation by T7 RNA Polymerase},
  author={Srabani Mukherjee and Luis G Brieba and Rui Sousa},
  journal={Cell},
  year={2002},
  volume={110},
  pages={81-91}
}
During transcription initiation, RNA polymerases appear to retain promoter interactions while transcribing short RNAs that are frequently released from the complex. Upon transition to elongation, the polymerase releases promoter and forms a stable elongation complex. Little is known about the changes in polymerase conformation or polymerase:DNA interactions that occur during this process. To characterize the transitions that occur in the T7 RNA polymerase transcription complex during initiation… CONTINUE READING