Structural Stability of Human Protein Tyrosine Phosphatase ρ Catalytic Domain: Effect of Point Mutations

@inproceedings{Pasquo2012StructuralSO,
  title={Structural Stability of Human Protein Tyrosine Phosphatase ρ Catalytic Domain: Effect of Point Mutations},
  author={Alessandra Pasquo and Valerio Consalvi and Stefan Knapp and Ivan Alfano and Matteo Ardini and Simonetta Stefanini and Roberta Chiaraluce},
  booktitle={PloS one},
  year={2012}
}
Protein tyrosine phosphatase ρ (PTPρ) belongs to the classical receptor type IIB family of protein tyrosine phosphatase, the most frequently mutated tyrosine phosphatase in human cancer. There are evidences to suggest that PTPρ may act as a tumor suppressor gene and dysregulation of Tyr phosphorylation can be observed in diverse diseases, such as diabetes… CONTINUE READING