Structural Rearrangement upon Fragmentation of the Stability Core of the ALS-Linked Protein TDP-43.

@article{Morgan2017StructuralRU,
  title={Structural Rearrangement upon Fragmentation of the Stability Core of the ALS-Linked Protein TDP-43.},
  author={Brittany R. Morgan and Jill A. Zitzewitz and Francesca Massi},
  journal={Biophysical journal},
  year={2017},
  volume={113 3},
  pages={
          540-549
        }
}
Amyotrophic lateral sclerosis (ALS) is the most common adult degenerative motor neuron disease. Experimental evidence indicates a direct role of transactive-response DNA-binding protein 43 (TDP-43) in the pathology of ALS and other neurodegenerative diseases. TDP-43 has been identified as a major component of cytoplasmic inclusions in patients with sporadic ALS; however, the molecular basis of the disease mechanism is not yet fully understood. Fragmentation within the second RNA recognition… CONTINUE READING
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