Structural Properties of HIV Integrase·Lens Epithelium-derived Growth Factor Oligomers*

Abstract

Integrase (IN) is the catalytic component of the preintegration complex, a large nucleoprotein assembly critical for the integration of the retroviral genome into a host chromosome. Although partial crystal structures of human immunodeficiency virus IN alone and its complex with the integrase binding domain of the host factor PSIP1/lens epithelium-derived… (More)
DOI: 10.1074/jbc.M110.114413

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