Structural Principles in the Development of Cyclic Peptidic Enzyme Inhibitors

Abstract

This review summarizes our studies in the development of small cyclic peptides for specifically modulating enzyme activity. Serine proteases share highly similar active sites but perform diverse physiological and pathological functions. From a phage-display peptide library, we isolated two mono-cyclic peptides, upain-1 (CSWRGLENHRMC) and mupain-1… (More)
DOI: 10.7150/ijbs.21597

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@inproceedings{Xu2017StructuralPI, title={Structural Principles in the Development of Cyclic Peptidic Enzyme Inhibitors}, author={Peng Xu and Peter Andreasen and Mingdong Huang}, booktitle={International journal of biological sciences}, year={2017} }